HCID 18923326, compound → HCID 18923549, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-bromo-8-[2-chloro-6-(N-acetyl-N-methylamino) benzyloxy]-2-methylimidazo[1,2-a]pyridine (103 mg) in tetrahydrofuran (2 ml) was added lithium aluminum hydride (16 mg) in several portions at 5° C. After the addition, the mixture was stirred for 2 hours at 5° C. and then quenched with aqueous saturated ammonium chloride solution. The separated organic layer was washed with aqueous saturated ammonium chloride solution, dried, and concentrated in vacuo. The residue was purified by preparative thin-layer chromatography (ethyl acetate:n-hexane =1:2, V/V) to give 3-bromo-8-[2-chloro-6-(N-ethyl-N-methylamino)benzyloxy]-2-methylimidazo[1,2-a]pyridine (41 mg).

Provenance & Evidence