Pyridine → HCID 23371830, compound

Participants

Reaction Steps

4.18 g (16.0 mmol) of ethyl 4-cycloheptylphenylcarbamate were treated with 1.3 g (16.0 mmol) of pyridine and 18 g (0.136 mol) of (RS)-4-methoxymethyl-1,3-dioxolan-2-one and stirred at 160° bath temperature for 20 hours. After cooling the reaction mixture was chromatographed on 400 g of silica gel 60 with ether. After recrystallization from isopropyl ether there were obtained 2.05 g of (RS)-3-[(4-cycloheptyl)phenyl]-5-methoxymethyl-oxazolidin-2-one as a white crystallizate. M.p.: 70°-72°.

Provenance & Evidence