HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(4-Aminophenyl)piperidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(4-Nitrophenyl)piperidin-4-one | HCID 3842562 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(4-Aminophenyl)piperidin-4-one | HCID 22220241 | 103.4% |
Reaction Steps
5.6 g of 1-(4-nitrophenyl)-4-piperidone were suspended in 60 ml of dioxan under argon, treated with 2.6 ml of triethylamine and 0.6 g of palladium-on-charcoal (5%) and hydrogenated at room temperature and normal pressure. Filtration and concentration yielded 5.0 g of 1-(4-aminophenyl)-4-piperidinone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05574055 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-081e7a810fdf4a13b85ad3f456a47a51 |
| Source note | uspto-grants-1996_11 |