HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-(3-Fluoro-4-hydroxybenzoyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | HCID 19043702 | HCID 19043702 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(3-Fluoro-4-hydroxybenzoyl)benzonitrile | HCID 19043765 | — |
Reaction Steps
A solution of 50g of 4-(3-fluoro-4-methoxy-benzoyl)benzonitrile in 550 ml of methylene chloride is treated with 70 ml of BBr3 at 5° C. and stirred at room temperature. 11 of 1M NaOH is added dropwise while cooling with ice. Then, the mixture is extracted with saturated aqueous NH4Cl solution and methylene chloride. The organic phase is washed with water and dried. After recrystallization from ether, there are obtained 34 g of 4-(3-fluoro-4-hydroxy-benzoyl)-benzonitrile, m.p. 168.5°-169.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05574071 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-8aa2f8806bed477c81c34741ae555e22 |
| Source note | uspto-grants-1996_11 |