HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorobenzene → N-(Adamantan-1-yl)-N'-(2,4-difluorophenyl)guanidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorobenzene | HCID 7964 | — |
| Reactant | 1-Adamantylcyanamide | HCID 12435846 | — |
| Reactant | 2,4-Difluoroaniline hydrochloride | HCID 21832305 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(Adamantan-1-yl)-N'-(2,4-difluorophenyl)guanidine | HCID 178512047 | — |
Reaction Steps
A single neck glass 100 ml round bottom flask was charged with chlorobenzene (20 ml), 2,4-difluoroaniline hydrochloride (prepared from the free base, Aldrich, by dissolving in 5% HCl in MeOH and concentrating, 2.0 g, 12 mmol) and 1-adamantylcyanamide (2.13 g, 12 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05574070 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-079199f940f7453ab0c9e1e6e9597938 |
| Source note | uspto-grants-1996_11 |