Sodium Hydroxide → HCID 19063402, compound

HRID 1900162Notes

Reaction equation

HRID 1900162 reaction equation
CN1S(=O)(=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]2[O:14][C:15](N(C3N=CC=CC=3)C(=O)C1=2)=[O:16].[OH-:26].[Na+]>[Na+].[Cl-]>[C:4]([O:14][CH2:15][O:16][C:4](=[O:14])[C:5]([CH3:10])=[CH2:6])(=[O:26])[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 65679Droxicam

Product 1

HCID 19063402HCID 19063402, compound

Reagents, catalysts & solvents 1

HCID 5234Sodium ChlorideSolvent2×

Procedure

50 mg samples of the polymer (Example 23), as finely divided powder, and 20 ml 0.9% aqueous NaCl were added to each of three reaction vials. To one of the vials was also added 0.1 ml esterase from porcine liver in 3.2M (NH4)2SO4, (Sigma E-3128, 250U). To another of the vials was added 0.1 ml 3.2M (NH4)2SO4. Using a pH-stat (Radiometer), the pH within each of the vials was kept constant at 8.0 by adding 0.1M NaOH. By recording the consumption of NaOH, the rates of hydrolysis were calculated. Over 45 hours at 37° C., the hydrolysis of the polymer with esterase was found to be 11 times faster than the control with (NH4)2SO4 without esterase. In the control containing polymer in 0.9% NaCl no hydrolysis was found (see FIG. 1 of the accompanying drawing).

Workup

  1. customof three reaction vials
  2. customthe consumption of NaOH
  3. customthe rates of hydrolysis
  4. customthe hydrolysis of the polymer with esterase

Sources & evidence

ORD record
ord-a4d4ab7325e34d0e853a0d0e11aeeea5
Source dataset
uspto-grants-1996_11
Patent number
US05574097

Reaction notes

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