1,2-Ethanedithiol → 2-(1,3-Dithiolan-2-yl)-phenylacetic acid methyl ester

Participants

Reaction Conditions

Reaction Steps

10 ml of 1,2-ethanedithiol (0.12 moles) and 115 ml of trifluoro diboro diethyletherate are added to a solution of 22 g (0.12 moles) of 2-formyl-phenylacetic acid methyl ester in 100 ml of methylene chloride at 20° C. The system is agitated at 20° C. for 48 hours. 152 ml of 5% sodium hydroxide are added, the phases are separated, the organic phase is dried over magnesium sulphate and the solvent is evaporated under vacuum at +30° C. In this manner 29.7 g of 2-(1,3-dithiolan-2-yl)-phenylacetic acid methyl ester are obtained in the form of a yellow liquid. This crude product is saponified without the need for further purification.

Provenance & Evidence