HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1900228Generated: October 30, 2026
Trifluoroacetic acid → 7-Benzyl-1-cyano-2-oxa-7-azabicyclo[3.3.0]octane
https://huagongshe.com/reaction/1900228
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzyl(methoxymethyl)((trimethylsilyl)methyl)amine | HCID 353442 | — |
| Reactant | 4,5-Dihydrofuran-2-carbonitrile | HCID 13624042 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-Benzyl-1-cyano-2-oxa-7-azabicyclo[3.3.0]octane | HCID 21704747 | — |
Reaction Steps
14.4 g (0.15 mol) of 4,5-dihydrofuran-2-carbonitrile are introduced in 300 ml of absolute methylene chloride, 1.8 g of triethylamine and 1.8 g of trifluoroacetic acid are added, and the mixture is warmed to 40° C. 42.6 g (0.15 mol) of N-benzyl-N-methoxymethyl-N-trimethylsilylmethylamine are added dropwise to this mixture which is then stirred at 40° C. for 15 hours. It is then washed with 50 ml of saturated sodium hydrogen carbonate solution, dried over MgSO4, concentrated and distilled twice.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05574161 |
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| Source dataset | uspto-grants-1996_11 |
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| ORD ID | ord-ee1860aab4bf4ac7beec01d2054018d8 |
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| Source note | uspto-grants-1996_11 |
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