Ethanol → (Hexahydro-1H-furo[3,4-c]pyrrol-3a-yl)methanamine

HRID 1900233Notes

Reaction equation

HRID 1900233 reaction equation
[NH2:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[CH2:6]C[CH2:4]2.C([OH:13])C>[Pd]>[NH2:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[CH2:6][O:13][CH2:4]2

Participants

4

Reactant 2

HCID 702EthanolHCID 22924372HCID 22924372, compound

Product 1

HCID 19960957(Hexahydro-1H-furo[3,4-c]pyrrol-3a-yl)methanamine

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

2.8 g (12.1 mmol) of 1-aminomethyl-7-azabicyclo-[3.3.0]octane are dissolved in 50 ml of ethanol and hydrogenated on 0.3 g of palladium-active charcoal at 100° C. and 100 bar. The catalyst is filtered off with suction and the filtrate is concentrated and distilled.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationdistilled

Sources & evidence

ORD record
ord-e8ca5092cac145d393a55fec6a75ff8f
Source dataset
uspto-grants-1996_11
Patent number
US05574161

Reaction notes

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