Tetrahydrofuran → HCID 54416378, compound

Participants

Reaction Steps

Dissolved N-methyl-2-[6,11-dihydro-dibenzo[b,e]oxepin-11-yl]-pentanamine (0.50 g, 1.70 mmol)in 20 mL of dry THF. Added triethylamine (0.28 mL, 0.21 g, 2.02 mmol) and ethyl chloroformate (0.18 mL, 0.20 g, 1.86 mmol). Stirred at room temperature for 16 hours. Added water, and extracted with ether. Dried combined organic extracts with MgSO4, filtered, and evaporated. Purified crude product by flash chromatography on silica gel eluting with dichloromethane. Combined appropriate fractions, and evaporated to give 0.45 g (73% yield) of ethyl [2-(6,11 -dihydro-dibenzo[b,e]oxepin-1-yl)-pentyl]-methylcarbamate as a colorless oil.

Provenance & Evidence