Methyl iodide → HCID 23372178, compound

HRID 1900252Notes

Reaction equation

HRID 1900252 reaction equation
[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[CH:6]([CH:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[I:23][CH3:24]>CO>[I-:23].[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[CH:6]([CH:16]3[CH2:17][CH2:18][N+:19]([CH3:24])([CH3:22])[CH2:20][CH2:21]3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 13358130HCID 13358130, compound

Product 1

HCID 23372178HCID 23372178, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dissolved 4-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-1-methyl-piperidine (1.0 g, 3.4 mmol) in 10 mL of methanol. Added iodomethane (0.71 g, 5.0 mmol), and stirred at room temperature for 18 hours. Filtered the precipitate to give 1.22 g (83% yield) of 4-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-1,1-dimethyl-piperidinium iodide as a white solid.

Workup

  1. filtrationFiltered the precipitate

Sources & evidence

ORD record
ord-f50b9a2d77234996bd3c78f3886ff2a3
Source dataset
uspto-grants-1996_11
Patent number
US05574173

Reaction notes

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