HRID1900266

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7841

Allyl bromide

C3H5Br

HCID6950261

rel-(2R,6S)-2,6-Dimethylpiperazine

C6H14N2

结构：CCN(CC)C(=O)c1cccc(C(Cl)c2cccc(O[Si](C)(C)C(C)(C)C)c2)c1

HCID21480391

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)C(=O)c1cccc(C(c2cccc(O)c2)N2CC(C)NC(C)C2)c1

HCID21480445

未命名化合物

结构：C=CCN1[C@H](C)CN(C(c2cccc(O)c2)c2cccc(C(=O)N(CC)CC)c2)C[C@@H]1C

HCID22865166

未命名化合物

PROCEDURE

实验过程

(±)-3-(α-(3,5-Dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide was prepared from (3-(3-((tert-butyldimethyl-silyl)oxy)-α-chlorobenzyl)-N,N-diethylbenzamide (Example 1, infra) and cis-2,6-dimethylpiperazine according to the methods of Example 1. This material was then alkylated with allyl bromide and deprotected by methods similar to that in Example 4 to give (±)-cis-3-(α-(4-allyl-3,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N -diethylbenzamide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9d71278593b4465390afd3c1ac4784e7
来源数据集: uspto-grants-1996_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05574159
来源说明: uspto-grants-1996_11

反应 SMILES

C([Si](C)(C)[O:6][C:7]1[CH:8]=[C:9]([CH:25]=[CH:26][CH:27]=1)[CH:10]([C:12]1[CH:13]=[C:14]([CH:22]=[CH:23][CH:24]=1)[C:15]([N:17]([CH2:20][CH3:21])[CH2:18][CH3:19])=[O:16])Cl)(C)(C)C.[CH3:30][C@H:31]1[CH2:36][NH:35][CH2:34][C@@H:33]([CH3:37])[NH:32]1.[CH2:38](Br)[CH:39]=[CH2:40]>>[CH3:30][CH:31]1[NH:32][CH:33]([CH3:37])[CH2:34][N:35]([CH:10]([C:12]2[CH:13]=[C:14]([CH:22]=[CH:23][CH:24]=2)[C:15]([N:17]([CH2:18][CH3:19])[CH2:20][CH3:21])=[O:16])[C:9]2[CH:25]=[CH:26][CH:27]=[C:7]([OH:6])[CH:8]=2)[CH2:36]1.[CH2:40]([N:32]1[C@@H:33]([CH3:37])[CH2:34][N:35]([CH:10]([C:12]2[CH:13]=[C:14]([CH:22]=[CH:23][CH:24]=2)[C:15]([N:17]([CH2:18][CH3:19])[CH2:20][CH3:21])=[O:16])[C:9]2[CH:25]=[CH:26][CH:27]=[C:7]([OH:6])[CH:8]=2)[CH2:36][C@H:31]1[CH3:30])[CH:39]=[CH2:38]