Water → HCID 131719641, compound

Participants

Reaction Steps

A mixture of 4.5 g of t-butyl (3R)-2-propyl-3-dodecanoyloxybutanoate obtained in (1) above 45 ml of methanol and 0.5 ml of concentrated sulfuric acid was refluxed for 40 hours and 50 ml of water was added thereto followed by ether extraction. The ether phase was dried over anhydrous sodium sulfate, and ether was distilled away, and the residue was distilled and 1.2 g of methyl (3R)-2-propyl-3-hydroxybutanoate of the following formula was obtained. b.p. 76°-81° C. (5.0 mm Hg), [α]D26 =2.9°(C-1.37, CHCl3) ##STR79##

Provenance & Evidence