HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzylpiperazine → 1-Benzyl-4-(benzothiophen-2-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | Benzo[b]thiophene-2-thiol | HCID 11073791 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Benzyl-4-(benzothiophen-2-yl)piperazine | HCID 21701623 | 46.5% |
Reaction Steps
To a solution of 2-mercaptobenzothiophene (1.8 g, 10.8 mmol) in toluene under nitrogen was added N-benzylpiperazine (1.88 ml, 10.8 mmol) and the mixture heated at reflux for 1.5 h. Left to cool, concentrated in vacuo and product recrystallised from diethyl ether-hexane to yield the title compound (1.55 g), m.p. 160°-161° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576319 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-e90b20a8dcfe47469ef17914148b360d |
| Source note | uspto-grants-1996_11 |