反应详情

To a solution of 1-benzyl-4-(benzothiophen-2-yl)piperazine (1.5 g, 4.9 mmol) in anhydrous dichloromethane (20 ml) at 0° C. under nitrogen was added 1-chloroethylchloroformate (0.68 ml, 6.37 mmol). The mixture was allowed to warm to room temperature, stirred for 1 h and concentrated in vacuo. The crude residue was dissolved in methanol (10 ml) and heated to reflux for 30 minutes, left to cool and the title compound collected by filtration (0.6 g), m.p. 240° C. (dec.).

1. concentrationconcentrated in vacuo
2. dissolutionThe crude residue was dissolved in methanol (10 ml)
3. temperatureheated
4. temperatureto reflux for 30 minutes
5. waitleft
6. temperatureto cool
7. filtrationthe title compound collected by filtration (0.6 g), m.p. 240° C. (dec.)