Methyl 3-aminopropanoate hydrochloride → Methyl N-[(furan-2-yl)methyl]-beta-alaninate

HRID 1900580Notes

Reaction equation

HRID 1900580 reaction equation
S1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11].Cl.NCCC(OC)=[O:19]>>[O:19]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11]

Participants

3

Reactant 2

HCID 2734767Methyl 3-aminopropanoate hydrochlorideHCID 23369385HCID 23369385, compound

Product 1

HCID 21824744Methyl N-[(furan-2-yl)methyl]-beta-alaninate

Procedure

Methyl 3-[(2-furanylmethyl)amino]propanoate (22) was prepared in the manner methyl 3-[(2-thienylmethyl)amino]propanoate (15) was prepared, as described above in Example 15, on a 6.5 mmol scale from methyl β-alaninate hydrochloride and furrural to yield 0.28 g (28%) of product.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-aca9a0377d7a4a4ca944a4c9f5aabea5
Source dataset
uspto-grants-1996_11
Patent number
US05576315

Reaction notes

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