Hydrazine → HCID 86748367, compound

HRID 1900583Notes

Reaction equation

HRID 1900583 reaction equation
[F:1][C:2]([F:15])([CH:7]([OH:14])[C:8]1[CH:13]=[CH:12][CH:11]=CN=1)[C:3]([NH:5][NH2:6])=[O:4].FC(F)(C(O)C1[S:25]C=CC=1)C(OCC)=O.NN>>[F:1][C:2]([F:15])([CH:7]([OH:14])[C:8]1[S:25][CH:11]=[CH:12][CH:13]=1)[C:3]([NH:5][NH2:6])=[O:4]

Participants

4

Reactant 3

HCID 9321HydrazineHCID 14249552Ethyl α,α-difluoro-β-hydroxy-2-thiophenepropanoateHCID 14976000HCID 14976000, compound

Product 1

HCID 86748367HCID 86748367, compound

Procedure

α,α-difluoro-β-hydroxy-2-thiophenepropanoic acid, hydrazide (26) was prepared in the same manner as α,α-difluoro-β-hydroxy-3-(2-pyridinyl)-propanoic acid, hydrazide (10), as described above in Example 10, on a 1.4 mmol scale from ethyl α,α-difluoro-β-hydroxy-2-thiophenepropanoate and hydrazine to yield 0.23 g (74%) of product. Analysis calculated for C7H8N2O2F2S (M.W. 222.21): C, 37.84; H, 3.63; N, 12.61. Found: C, 37.72; H, 3.51; N, 12.42.

Sources & evidence

ORD record
ord-e7cdd3a0287048a59b3bf5e467836e78
Source dataset
uspto-grants-1996_11
Patent number
US05576315

Reaction notes

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