HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → HCID 9995187, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Benzo-1,3-dioxole-5-methylamine | HCID 75799 | — |
| Reactant | 4-chloroquinazoline-6-carbonitrile | HCID 10012727 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 9995187 | HCID 9995187 | 89% |
Reaction Steps
15 ml of isopropyl alcohol, 75 mg of triethylamine and 125 mg of piperonylamine were added to 140 mg of 4-chloro-6-cyanoquinazoline. The obtained mixture was heated under reflux for 5 hours and filtered to recover a precipitate. This precipitate was introduced to a silica gel column, followed by eluting with ethyl acetate to give 200 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576322 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-0ea45d04cdf047c4b46941ca9715179a |
| Source note | uspto-grants-1996_11 |