HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-Chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanoquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Chloro-4-methoxybenzylamine | HCID 738038 | — |
| Reactant | 2,4-Dichloroquinazoline-6-carbonitrile | HCID 18796670 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-Chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanoquinazoline | HCID 21184004 | 86.7% |
Reaction Steps
3.9 g of 3-chloro-4-methoxybenzylamine, 3.97 g of triethylamine and 200 ml of 2-propanol were added to 4 g of 2,4-dichloro-6-cyanoquinazoline. The obtained mixture was refluxed for 30 minutes, cooled to room temperature and filtered to recover a crystalline precipitate. The precipitate was washed with water and chloroform successively to give 5.563 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576322 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-f71995dee960411fb531830d79f06dcd |
| Source note | uspto-grants-1996_11 |