Pyridine → 4-(3-Methanesulfonylamino-4-chlorobenzyl)amino-6-chloroquinazoline

HRID 1900672Notes

Reaction equation

HRID 1900672 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][C:7]1[CH:8]=[C:9]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:10][NH:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([Cl:22])[CH:20]=2)[N:15]=[CH:14][N:13]=1.N1C=CC=CC=1>O>[CH3:1][S:2]([NH:6][C:7]1[CH:8]=[C:9]([CH:23]=[CH:24][C:25]=1[Cl:26])[CH2:10][NH:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([Cl:22])[CH:20]=2)[N:15]=[CH:14][N:13]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 187967134-(3-Amino-4-chlorobenzyl)amino-6-chloroquinazoline

Product 1

HCID 187966724-(3-Methanesulfonylamino-4-chlorobenzyl)amino-6-chloroquinazoline

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

75 μl of methanesulfonyl chloride was added to a mixture comprising 100 mg of 4-(3-amino-4-chlorobenzyl)amino-6-chloroquinazoline and 3 ml of pyridine. The obtained mixture was stirred at room temperature for 1.5 hours. 20 ml of water was added in portions to the reaction mixture to precipitate crystals. The crystals were recovered by filtration, washed with water and dried to give 109 mg of the title compound.

Workup

  1. customto precipitate crystals
  2. filtrationThe crystals were recovered by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-2c6582a4ee014104b118d1ebe02bdc4d
Source dataset
uspto-grants-1996_11
Patent number
US05576322

Reaction notes

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