HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 2-Morpholino-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 2-Chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline | HCID 21183984 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Morpholino-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline | HCID 21184038 | 79.8% |
Reaction Steps
A mixture comprising 338 mg of 2-chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline, 435 mg of morpholine and 20 ml of isopropyl alcohol was heated under reflux for 3 hours, followed by the addition of 30 ml of water under heating. The precipitate thus formed was recovered by filtration and washed with 30 ml of water and 30 ml of ethyl acetate. Thus, 310 mg of the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576322 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-0d2acbfed5dd4d90b2bbd34b0e793de7 |
| Source note | uspto-grants-1996_11 |