HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-Amino-4-(3,4-methylenedioxybenzyl)amino-6-chloroquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-((1,3-Benzodioxol-5-ylmethyl)amino)-2,6-dichloro quinazoline | HCID 22339865 | — |
| Product | 2-Amino-4-(3,4-methylenedioxybenzyl)amino-6-chloroquinazoline | HCID 21183928 | 44% |
Reaction Steps
2.0 g of 2,6-dichloro-4-(3,4-methylenedioxybenzyl)aminoquinazoline was heated to 120° C. in 50 ml of ethanolic ammonia put in a pressure vessel for 18 hours, cooled and concentrated under a reduced pressure. The obtained residue was introduced to a silica gel column and eluted with a chloroform/methanol (9:1) mixture to give 830 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576322 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-c412790c5d7e4387951cb2fb9aa00a25 |
| Source note | uspto-grants-1996_11 |