HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(4-Ethoxycarbonylpiperidino)-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Reactant | 2-Chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline | HCID 21183984 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-(4-Ethoxycarbonylpiperidino)-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline | HCID 21183900 | 83% |
Reaction Steps
3.71 g of ethyl isonipecotate, 2.38 g of triethylamine and 10 ml of 2-propanol were added to 1 g of 2-chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline. The obtained mixture was refluxed for 1 hour and cooled to room temperature. The crystals thus precipitated were recovered by filtration and washed with water and ether successively to give 1.126 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576322 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-2cdacd7caff044ab9bf6d89ed077f58c |
| Source note | uspto-grants-1996_11 |