HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1900694Generated: October 29, 2026
Hydrochloric Acid → 2-(4-Carboxypiperidino)-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline
https://huagongshe.com/reaction/1900694
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-(4-Ethoxycarbonylpiperidino)-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline | HCID 21183900 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(4-Carboxypiperidino)-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline | HCID 21183931 | 38.8% |
Reaction Steps
20 ml of ethanol and 2.0 ml of a 1N aqueous solution of sodium hydroxide were added to 318 mg of 2-(4-ethoxycarbonylpiperidino)-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline. The obtained mixture was stirred at 50° C. for 30 minutes and neutralized with 1N hydrochloric acid. The crystal thus precipitated was recovered by filtration and purified by silica gel column chromatography (chloroform/methanol) to give 116 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05576322 |
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| Source dataset | uspto-grants-1996_11 |
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| ORD ID | ord-9905f343d38140518be934aa010834f4 |
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| Source note | uspto-grants-1996_11 |
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