HCID 54296403, compound → HCID 23369572, compound

Participants

Reaction Conditions

Reaction Steps

The obtained 7-n-hexyl-1,2,3,4,5,6,7,8-octahydroquinoline-2,5-dione (11.0 g) was suspended in decalin (150 ml). To the suspension, 10% palladium-on-carbon (3.7 g) was added, followed by stirring at 200° C. for 17 hours. After completion of the reaction, the insoluble matter was collected by filtration, washed with ether, then extracted with a solvent mixture of chloroform-methanol (2:1). The extract was dried to solidity under reduced pressure. Recrystallization from methanol yielded 9.56 g of 7-n-hexyl-5-hydroxycarbostyril as colorless needles having a melting point of 252°-255° C. (dec.) (87.9%).

Provenance & Evidence