Diazomethane → 2,3,6,7,8,9-Hexahydro-2-methoxymethyl-5-methylfuro-[2,3-f]quinoline-7-one

Participants

Reaction Steps

To a solution of 2,3,6,7,8,9-hexahydro-2-hydroxymethyl -5-methylfuro-[2,3-f]quinoline-7-one (300 mg) in tetrahydrofuran (100 ml), silica gel (10 g) and a solution of diazomethane in ether (200 ml) were added, and stirred at room temperature for 36 hours. After completion of the reaction, the solvent was distilled off, and the residue was purified by silica gel column chromatography to obtain 280 mg of the target product as a pale yellow powder (88%).

Provenance & Evidence