Dimethylformamide → HCID 23369665, compound

Participants

Reaction Steps

The compound obtained in Example 158 (0.50 g, 2.06 mmol) dissolved in dimethylformamide (12 ml) was combined with 10% palladium-carbon (0.30 g), then stirred in the stream of hydrogen for 1.5 hour. From the reaction mixture, palladium-carbon was filtered off. The filtrate was condensed under reduced pressure, and purified by silica gel column chromatography (eluent; chloroform: ammonia=methanol 15:1). 0.33 g of the tile compound was obtained as pale yellow crystals (74.0%). They were recrystallized from a solvent mixture of chloroform--methanol--n-hexane to obtain pale yellow prisms of the title compound (mp.: 233°-236° C. (dec.)).

Provenance & Evidence