Diethyl Ether → HCID 57022354, compound

Participants

Reaction Steps

2-Carbobenzyloxyglycylaminomethyl-5-methyl-2,3,6,7-tetrahydrofuro-[2,3-f]quinoline-7-one (2.00 g, 4.75 mmol) was dissolved in dimethylformamide (250 ml). To the obtained solution, 10% palladium-on-carbon (2.00 g) was added, followed by stirring at room temperature for 3 hours in the atmosphere of hydrogen. The reaction mixture was filtered, and the filtrate was condensed under reduced pressure. The resultant residue was dissolved in methanol (20 ml), to which 4N-HCl/dioxane (1.2 ml) was added, and the mixture was condensed under reduced pressure at room temperature. The resultant residue was submitted to a recrystallizing procedure using methanol--ether to obtain 1.45 g of the title compound as pale yellow powdery crystals (94.6%).

Provenance & Evidence