Ethyl 2-methylacetoacetate → HCID 23369854, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-amino-4-ethoxytoluene (590 mg, 3.99 mmol) and ethyl-2-methylacetoacetate (560 mg, 3.88 mmol) was stirred in a bath of 150° C. for 4 hours. The resultant mixture was subjected to silica gel column chromatography (developer: ethyl acetate--n-hexane), and the fraction containing the target substance was condensed, followed by recrystallizing from a solvent mixture of chloroform--n-hexane. As a result, 252 mg of the title compound was obtained as yellow powder (25.9%).

Provenance & Evidence