N,N-Dimethylaniline → HCID 23369617, compound

Participants

Reaction Conditions

Reaction Steps

5-Allyloxy-3,4,8-trimethylcarbostyril (1.02 g, 420 mmol) was dissolved in N,N-dimethylaniline (20 ml), and the mixture was stirred in a bath of 200° C. for 2 hours. The reaction mixture was condensed under reduced pressure, to which chloroform and aqueous 2N-NaOH solution were added, then extracted into the aqueous phase. The aqueous phase was neutralized with conc. HCl solution, followed by extracting with chloroform--methanol (10:1), drying, and condensing. The resultant residue was recrystallized from chloroform--methanol--ether. As a result, 989 mg of the title compound was obtained as pale yellow needles (97.0%).

Provenance & Evidence