Ammonia → HCID 23369701, compound

HRID 1900793Notes

Reaction equation

HRID 1900793 reaction equation
C([O:3][C:4]([CH:6]1[O:20][C:9]2=[C:10]3[C:15](=[C:16]([CH3:18])[CH:17]=[C:8]2[CH2:7]1)[NH:14][C:13](=[O:19])[CH2:12][CH2:11]3)=O)C.[NH3:21].CO>C(Cl)(Cl)Cl>[NH2:21][C:4]([CH:6]1[O:20][C:9]2=[C:10]3[C:15](=[C:16]([CH3:18])[CH:17]=[C:8]2[CH2:7]1)[NH:14][C:13](=[O:19])[CH2:12][CH2:11]3)=[O:3]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 23369779HCID 23369779, compound

Product 1

HCID 23369701HCID 23369701, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The compound obtained in Example 258 (1 g, 3.63 mmol) was dissolved in chloroform (20 ml). To the solution, saturated ammonia--methanol solution (50 ml) was added. The vessel containing the mixture was sealed, and the content was stirred at room temperature for 24 hours. After completion of the reaction, the solvent was distilled off under reduced pressure. 0.88 g of the title compound was obtained as a white solid (99%).

Workup

  1. additionThe vessel containing the mixture
  2. customwas sealed
  3. customAfter completion of the reaction
  4. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-012fd1aacac94707b359e1c0d8de2bf7
Source dataset
uspto-grants-1996_11
Patent number
US05576324

Reaction notes

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