反应详情

2-Amino-4-methoxytoluene (13.2 g, 89.7 mmol) and pyridine (10 ml) were dissolved in acetone (112 ml), to which α-methylcinnamoylchloride (19.4 g, 107.6 mmol) was added while cooling and stirring. The mixture was stirred overnight at room temperature. The solvent was evaporated, and the residue was dissolved in chloroform, washed with water, dried, and condensed. The residue was purified by alumina chromatography (chloroform), and subjected to recrystallization with chloroform--n-hexane to obtain 21.27 g of the title compound as colorless crystals (84.4%).

1. additionwas added
2. temperaturewhile cooling
3. stirringThe mixture was stirred overnight at room temperature
4. customThe solvent was evaporated
5. dissolutionthe residue was dissolved in chloroform
6. washwashed with water
7. customdried
8. customcondensed
9. customThe residue was purified by alumina chromatography (chloroform)
10. customsubjected to recrystallization with chloroform