反应详情

温度

125 °C

N-(5-Methoxy-2-methylphenyl)α-methylcinnamamide (21.3 g, 75.8 mmol) and aluminum chloride (50.4 g, 378 mmol) were combined with chlorobenzene (158 ml), and heated in a bath at 125° C. for 45 minutes while stirring. After cooling, the mixture was poured into ice-water, to which hexane was added. Precipitated crystals were collected by filtration, and dissolved in chloroform-methanol (4:1). After drying and condensing, the resultant residue was washed with chloroform to obtain 12.22 g of the title compound as pale brown crystals (85.3%).

1. temperatureAfter cooling
2. additionwas added
3. customPrecipitated crystals
4. filtrationwere collected by filtration
5. dissolutiondissolved in chloroform-methanol (4:1)
6. customAfter drying
7. customcondensing
8. washthe resultant residue was washed with chloroform