反应详情

温度

200 °C

N,N-dimethylaniline (10 ml) was added to 5-allyloxy-3,8-dimethylcarbostyril (4.32 g, 18.9 mmol), and stirred for 2 hours and 40 minutes in a bath of 200° C. in the atmosphere of argon. After cooling, hexane was added. Precipitated crystals were collected by filtration, and purified by silica gel chromatography (chloroform:methanol =10:1). The purified product was subjected to recrystallization (chloroform-n-hexane) to obtain 3.86 g of the title compound as colorless crystals (89.4%).

1. temperatureAfter cooling
2. customPrecipitated crystals
3. filtrationwere collected by filtration
4. custompurified by silica gel chromatography (chloroform:methanol =10:1)
5. customThe purified product was subjected to recrystallization (chloroform-n-hexane)