HCID 54330815, compound → HCID 23369784, compound

HRID 1900838Notes

Reaction equation

HRID 1900838 reaction equation
C([O:5][C:6]1[CH:15]=[CH:14][C:13]([CH3:16])=[C:12]2[C:7]=1[CH2:8][C:9]([CH3:19])([CH3:18])[C:10](=[O:17])[NH:11]2)C=CC>CN(C)C1C=CC=CC=1.CCCCCC>[OH:5][C:6]1[C:15]([CH:7]([CH3:8])[CH:6]=[CH2:15])=[CH:14][C:13]([CH3:16])=[C:12]2[C:7]=1[CH2:8][C:9]([CH3:18])([CH3:19])[C:10](=[O:17])[NH:11]2

Participants

4

Reactant 1

HCID 54330815HCID 54330815, compound

Product 1

HCID 23369784HCID 23369784, compoundYield 179.6%

Reagents, catalysts & solvents 2

HCID 949N,N-DimethylanilineSolventHCID 8058HexaneSolvent

Procedure

A solution of 5-(2-butenyloxy)-3,3,8-trimethyl-3,4-dihydrocarbostyril (1.9 g, 7.3 mmol) in N,N-dimethylaniline (5 ml) was stirred at 210° C. for 7 hours in the stream of argon gas. After spontaneous cooling, the reaction mixture was diluted with hexane, and the precipitated crystals were collected by filtration. The obtained crude crystals were recrystallized from ethyl acetate-hexane to obtain 1.7 g of the title compound as colorless needles (89.3%).

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. customThe obtained crude crystals
  3. customwere recrystallized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-b5ec7560d8db4f77be58f24d5ab41a93
Source dataset
uspto-grants-1996_11
Patent number
US05576324

Reaction notes

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