3-Chloro-2-methyl-1-propene → HCID 23369594, compound

HRID 1900842Notes

Reaction equation

HRID 1900842 reaction equation
[CH2:1]([C:3]1[C:4](=[O:15])[NH:5][C:6]2[C:11]([CH:12]=1)=[C:10]([OH:13])[CH:9]=[CH:8][C:7]=2[CH3:14])[CH3:2].Cl[CH2:17][C:18]([CH3:20])=[CH2:19]>C(Cl)(Cl)Cl.CCCCCC>[CH2:1]([C:3]1[C:4](=[O:15])[NH:5][C:6]2[C:11]([CH:12]=1)=[C:10]([O:13][CH2:19][C:18]([CH3:20])=[CH2:17])[CH:9]=[CH:8][C:7]=2[CH3:14])[CH3:2]

Participants

4

Reactant 2

HCID 112413-Chloro-2-methyl-1-propeneHCID 23369646HCID 23369646, compound

Product 1

HCID 23369594HCID 23369594, compoundYield 75.1%

Reagents, catalysts & solvents 1

HCID 21585165Chloroform hexaneSolvent

Procedure

Using 3-ethyl-5-hydroxy-8-methylcarbostyril (0.91 g, 4.87 mmol) and 3-chloro-2-methyl-1-propene (0.485 g, 5.36 mmol), the procedure of Reference Example 31 was followed (reaction, post-treatment, and recrystallization from chloroform-n-hexane) to obtain 0.94 g of the title compound as pale brown crystals (75.1%).

Sources & evidence

ORD record
ord-e77bf4913191497aaa917c83096cbbd7
Source dataset
uspto-grants-1996_11
Patent number
US05576324

Reaction notes

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