Hydrochloride methanol → HCID 86749997, compound

Participants

Reaction Steps

2-(2'-Amino-3'-tritylmercaptopropionyl)aminomethyl-5-methyl-2,3,6,7-tetrahydrofuro[2,3-f]quinoline-7-one (1.05 g, 1.82 mmol) was dissolved in a mixture of methanol (5 ml) and chloroform (5 ml). To the resultant solution, 5% HCl/methanol (1.50 ml, 2.06 mmol) was added dropwise while cooling with ice-water. The mixture was stirred at room temperature for 20 minutes. The solvent was distilled off under reduced pressure. When the residue was recrystallized from methanol-ether, 879 mg of a hydrochloric acid salt of the first component was obtained as pale yellow crystals (78.8%).

Provenance & Evidence