Hydrogen Sulfide → HCID 23370006, compound

Participants

Reaction Steps

In a similar manner to Example 1, starting material step (b), the product of step (e) (600 mg), pyridine (42 ml), triethylamine (6 ml) and H2S gas were reacted to give t-butyl 2-(2-ethoxyethyl)-3-(4-[3-(4-thiocarbamoylbenzoyl)ureido]phenyl)propionate (585 mg) as a yellow solid: m.p. 199°-201° C.; NMR Spectrum (DMSO-d6) 1.10 (3H, t), 1.30 (9H, s), 1.70 (2H, m), 2.62 (1H, m), 2.72 (2H, m), 3.37 (4H, m), 7.15 (2H, d), 7.49 (2H, d), 7.95 (2H, d), 8.03 (2H, d), 9.67 (1H, br s), 10.06 (1H, br s), 10.72 (1H, s), 11.09 (1H, s); Mass Spectrum m/Z 522 (M+H)+.

Provenance & Evidence