Acetone → HCID 23370048, compound

Participants

Reaction Steps

In a similar manner to Example 1, the product from step (d) (380 mg), iodomethane (2 ml) and acetone (40 ml) were reacted at ambient temperature and the product so obtained was reacted with ammonium acetate (800 mg), ethanol (40 ml) and dichloromethane (20 ml). This yielded an oily residue which was purified by column chromatography on silica eluting with 10% ethanol/dichloromethane to give ethyl N-[N-(4-amidinobenzoyl)carbamoyl]piperidin-4-ylmethoxyacetate (210 mg) which was used without further purification.

Provenance & Evidence