HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 131719709, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | (2s)-Glycidyl indol-4-yl ether | HCID 10943254 | — |
| Reactant | 3,4-Dihydrospiro[naphthalene-1(2H),4′-piperidin]-2-one | HCID 21268329 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 131719709 | HCID 131719709 | — |
Reaction Steps
The title compound was prepared in similar fashion from (S)-(+)-4-(oxiranylmethoxy)-1H-indole and 3,4-dihydro-2-oxospiro[naphthalene-1(2H),4'-piperidine]. The resulting free base was dissolved in ethyl acetate, and precipitated with one equivalent of oxalic acid in ethyl acetate in 68% overall yield. FDMS m/e=404 (M+ of free base). α[D]589 =-15.81 (c=0.51, methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576321 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-acb0bcbd8fea42c58275c03368ec9ea4 |
| Source note | uspto-grants-1996_11 |