HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-(4-Indolyloxy)-3-[4-(2-naphthyl)piperazin-1-yl]propane oxalate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(Naphthalen-2-yl)piperazine | HCID 2760172 | — |
| Reactant | 4-(3-chloropropoxy)-1H-indole | HCID 11694169 | — |
| Product | 1-(4-Indolyloxy)-3-[4-(2-naphthyl)piperazin-1-yl]propane oxalate | HCID 21268316 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
1-(4-indolyloxy)-3-chloropropane (0.159 g, 0.75 mmol), 1-(2-naphthyl)piperazine (0.161 g, 0.75 mmol) and sodium carbonate (0.201 g, 1.89 mmol) were mixed together in 7 mL dimethylformamide and heated at 100° C. for 18 h. Evaporation of dimethylformamide, dilution with water and extractions with ethyl acetate provided 0.303 g. of oil. Crystallization as the oxalate salt from methanol provided 0.083 g of colorless crystals. Mp 209° C. Mass spectrum, m+ =385. Anal (C27H29N3O5) theory C, 68.20; H, 6.15; N, 8.84; found C, 68.47; H, 6.33; N, 8.60.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576321 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-22be1047caab4c1ba757f1e21bae960f |
| Source note | uspto-grants-1996_11 |