Trifluoroacetic acid → HCID 21268229, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 6-chloro-2-(4-hydroxy-N-t-butoxycarbonylpiperidin-4-yl)benzo[b]thiophene (1.04 g, 2.83 mmol) in methylene chloride (30.0 ml) was treated with 4.36 ml of trifluoroacetic acid and stirred at 23° C. for 4 hours. The reaction was concentrated to a foam under reduced pressure and the residue chromatographed (silica gel, CHCl3 /MeOH 95:5) to give 0.640 g (90%) of a tan powder. FDMS m/e=250 (M+ of free base)

Provenance & Evidence