HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 3-[4-(7-Chloro-3-indolyl)-1,2,3,6-tetra-hydropyridin-1-yl)-1-(4-indolyloxy)propane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(3-chloropropoxy)-1H-indole | HCID 11694169 | — |
| Reactant | 7-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | HCID 18545849 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-[4-(7-Chloro-3-indolyl)-1,2,3,6-tetra-hydropyridin-1-yl)-1-(4-indolyloxy)propane | HCID 54404786 | — |
Reaction Steps
The title compound was prepared in a fashion similar to that described in Example 99 using 1-chloro-3-(1H-indole-4-oxy)propane (0.446 g, 2.15 mmol) and 7-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (0.500 g, 2.13 mmol) in the presence of 2.0 equivalents of potassium carbonate (0.593 g, 4.3 mmol) in dimethylformamide at 90° C. Yield 0.190 g (22%) of a tan foam. mp 166°-169° C. FDMS m/e=405 (M+ of free base).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576321 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-04000310b27846b8a585e5df08b0f6df |
| Source note | uspto-grants-1996_11 |