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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1900987Generated: October 30, 2026

Potassium Carbonate → 3-[4-(6-Chloro-3-indolyl) piperidin-1-yl]-1-(4-indolyloxy)propane

https://huagongshe.com/reaction/1900987

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant4-(3-chloropropoxy)-1H-indoleHCID 11694169—
Reactant6-Chloro-3-piperidin-4-YL-1H-indoleHCID 12072040—
SolventDimethylformamideHCID 6228—
Product3-[4-(6-Chloro-3-indolyl) piperidin-1-yl]-1-(4-indolyloxy)propaneHCID 21268314—

Reaction Steps

The title compound was prepared in a fashion similar to that described in Example 99 using 1-chloro-3-(1H-indole-4-oxy)propane (0.446 g, 2.15 mmol) and 6-chloro-3-(piperidin-4-yl)-1H-indole (0.500 g, 2.13 mmol) in the presence of 2.0 equivalents of potassium carbonate (0.593 g, 4.3 mmol) in dimethylformamide at 90° C. Yield 0.330 g (37%) of a colorless foam. FDMS m/e=407 (M+ of free base).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05576321
Source datasetuspto-grants-1996_11
ORD IDord-e56bb7fcd13141aa81f78d398a7c9aac
Source noteuspto-grants-1996_11