HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 3-[4-(6-Chloro-3-indolyl) piperidin-1-yl]-1-(4-indolyloxy)propane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(3-chloropropoxy)-1H-indole | HCID 11694169 | — |
| Reactant | 6-Chloro-3-piperidin-4-YL-1H-indole | HCID 12072040 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-[4-(6-Chloro-3-indolyl) piperidin-1-yl]-1-(4-indolyloxy)propane | HCID 21268314 | — |
Reaction Steps
The title compound was prepared in a fashion similar to that described in Example 99 using 1-chloro-3-(1H-indole-4-oxy)propane (0.446 g, 2.15 mmol) and 6-chloro-3-(piperidin-4-yl)-1H-indole (0.500 g, 2.13 mmol) in the presence of 2.0 equivalents of potassium carbonate (0.593 g, 4.3 mmol) in dimethylformamide at 90° C. Yield 0.330 g (37%) of a colorless foam. FDMS m/e=407 (M+ of free base).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576321 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-e56bb7fcd13141aa81f78d398a7c9aac |
| Source note | uspto-grants-1996_11 |