Piperonylamine → HCID 21268275, compound

HRID 1901005Notes

Reaction equation

HRID 1901005 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][C:3]=1[O:11][CH3:12].O.Cl.[NH:15]1[CH2:20][CH2:19][C:18](=O)[CH2:17][CH2:16]1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:18]3[CH2:19][CH2:20][NH:15][CH2:16][CH:17]=3)=[CH:7][NH:8]2)=[CH:4][C:3]=1[O:11][CH3:12]

Participants

3

Reactant 2

HCID 2723901PiperonylamineHCID 131134936-Chloro-5-methoxy-1H-indole

Product 1

HCID 21268275HCID 21268275, compound

Procedure

The title compound was prepared in a fashion similar to that described in Preparation 30 from 6-chloro-5-methoxyindole (2.0 g, 11 mmol) and 4-piperidone hydrochloride hydrate (3.4 g, 22 mmol). The product was isolated as a yellow solid. Yield 2.4 g (83%). mp 222°-224° C. FDMS m/e=264 (M+ of free base).

Workup

  1. customThe product was isolated as a yellow solid

Sources & evidence

ORD record
ord-283b5151602841f8946cbcebe9ef97c4
Source dataset
uspto-grants-1996_11
Patent number
US05576321

Reaction notes

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