HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloroindole → 5-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloroindole | HCID 87110 | — |
| Reactant | Piperonylamine | HCID 2723901 | — |
| Product | 5-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | HCID 3050532 | — |
Reaction Steps
The title compound was prepared in a fashion similar to that described in Preparation 30 from 5-chloroindole (3.0 g, 20 mmol) and 4-piperidone hydrochloride hydrate (6.0 g, 40 mmol). The product was isolated as a yellow solid. Yield 1.45 g (31%). mp 185°-188° C. FDMS m/e=234 (M+ of free base).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05576321 |
| Source dataset | uspto-grants-1996_11 |
| ORD ID | ord-65c32c349dda47f5ac9399130b849b5e |
| Source note | uspto-grants-1996_11 |