3,5-Di-tert-butyl-4-hydroxybenzoic acid → HCID 23370131, compound

Participants

Reaction Steps

A solution of 1-(2-amino-4-fluorophenyl)-3-heptyl-3-methylurea (0.82 g), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride (0.67 g) and 3,5-di-t-butyl-4-hydroxybenzoic acid (0.88 g) dissolved in dichloromethane (10 ml) was stirred at room temperature overnight. The reaction solution was washed with water, saturated saline, dried over anhydrous MgSO4, and the solvent was distilled off. Purification of the residue by a silica gel column chromatography gave N-[5-fluoro-2-(3-heptyl-3-methylureido)phenyl]-3,5-di-t-butyl-4-hydroxybenzamide (0.84 g, 56%).

Provenance & Evidence