Octanoic Acid → HCID 23370109, compound

Participants

Reaction Steps

n-caprylic acid (0.32 g), diphenylphosphoryl azide (0.53 ml) and triethylamine (0.34 ml) were stirred in 10 toluene (5 ml) at room temperature for 3 hrs. and additionally for 2 hrs. at 80°-90° C. To the mixture was added under ice-cooling N-(2-amino-4-methoxyphenyl)-3,5-di-t-butyl-4-hydroxybenzamide (0.44 g), and the mixture was stirred overnight while returning slowly to room temperature. The solvent was distilled off and the residue was purified by a silica gel column chromatography (chloroform) to give N-[2-(3-heptylureido)-4-methoxyphenyl]-3,5-di-t-butyl-4-hydroxybenzamide (0.57 g, 93%) as a non-crystallizable solid.

Provenance & Evidence