3,5-Di-tert-butyl-4-hydroxybenzoic acid → HCID 23370097, compound

Participants

Reaction Steps

A mixture of 1-(4-amino-3-pyridyl)-3-heptylurea (0.50 g), 3,5-di-t-butyl-4-hydroxybenzoic acid (0.60 g) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride (0.46 g) was stirred in dichloromethane (10 ml) at room temperature overnight. The reaction solution was washed with water, saturated saline and dried over anhydrous MgSO4. The solvent was distilled off and the residue was purified by a silica gel column chromatography (chloroform:methanol=20:1) to give N-[3-(3-heptylureido)-4-pyridyl]-3,5-di-t-butyl-4-hydroxybenzamide (0.15 g, 16%) as crystals.

Provenance & Evidence