N-((1,1-Dimethylethoxy)carbonyl)-S-(triphenylmethyl)-L-cysteine → HCID 67748594, compound

HRID 1901083Notes

Reaction equation

HRID 1901083 reaction equation
Cl.Cl.[N:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][O:10][C:11](=[O:26])[C:12]1([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.[C:27]([O:31][C:32]([NH:34][C@H:35]([C:57](O)=[O:58])[CH2:36][S:37][C:38]([C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=1)([C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)=[O:33])([CH3:30])([CH3:29])[CH3:28]>>[N:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][O:10][C:11](=[O:26])[C:12]1([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])[CH2:17][CH2:16][N:15]([C:57](=[O:58])[C@H:35]([CH2:36][S:37][C:38]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)([C:51]2[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=2)[C:45]2[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=2)[NH:34][C:32]([O:31][C:27]([CH3:30])([CH3:28])[CH3:29])=[O:33])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 11167161N-((1,1-Dimethylethoxy)carbonyl)-S-(triphenylmethyl)-L-cysteineHCID 131719719HCID 131719719, compound

Product 1

HCID 67748594HCID 67748594, compound

Procedure

4-(2-methylbenzyl)isonipecotic acid 2-pyridylmethyl ester bis HCl salt was coupled to N-t-butoxycarbonyl-S-trityl-L-Cysteine utilizing the procedure described in Example 1, Step 7 to afford the product as a white foam.

Sources & evidence

ORD record
ord-85c249c3f73c4497a3f06f809d2e4d67
Source dataset
uspto-grants-1996_11
Patent number
US05576313

Reaction notes

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